Primary Pulmonary Choriocarcinoma: a Case Report

Dawit Kebede Huluka, Temesgen Damtew Nurye, Tewodros Haile Gebremariam, Amsalu Bekele Binegdie, Max O’Donnel, Sam Parsia, Charles Bruce Sherman


Primary pulmonary choriocarcinoma (PPC) is a rare malignant tumor of the lung. It is classified as one of the primary extragonadal choriocarcinomas (EGCC), which often involve midline structures such as the mediastinum, retroperitoneum, intracranium, stomach, intestines, bladder, and prostate; and have two unique characteristics: they are not associated with abnormal gestation and are not part of a germ cell neoplasm involving the reproductive organs. Diagnosis of PPC is often challenging and treatment is usually ineffective. We present the first case of PCC reported from East Africa and one of only 56 casesreported in the literature.

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Snoj Ziga, Kocijancic Igor, Skof Erik. Primary pulmonary choriocarcinoma.Radiol Oncol.

; 51(1):1–7.

UsahKini, Babu MK. Primary Pulmonary Choriocarcinoma: Is It Still an Enigma? Indian J

Chest Dis Allied Sci. 2007; 49:219-226.

Hainsworth JD, Greco FA. Extragonadal germ cell tumour and unrecognized germ cell

tumours. Semin Oncol. 1992; 19(2):119-127.

Serno Jorge, Zeppernick F, Jäkel J, Schrading S, Maass N, Meinhold-Heerlein I, et al.

Primary pulmonary choriocarcinoma: case report and review of the literature.

GynecolObstet Invest. 2012; 74(2):171-176.

Umemori Y, Hiraki A, Age K, Murkami T, Maeda T, Matsuda E, et al. Primary

choriocarcinoma of the lung. Anticancer Res. 2004; 24:1905-1910.

Zapatero J, Bellon J, Baamonde C, Aragoneses FG, Cubillo J, Orusco E, et al. Primary

choriocarcinoma of the lung: presentation of a case and review of the literature. Scand J

ThoracCardiovasc Surg. 1982:16(3):279-281.

Vicier Cecile, TabouretEmeline, Tallet Agnes, Goncalves Anthony, Chetaille Bruno,

Viens Patrice, et al. BetaHCG secretion by a pulmonary adenocarcinoma. World Journal of

Surgical Oncology. 2013;11:228.

Tsai JR, Chong IW, Hung JY, Tsai KB. Use of urine pregnancy test for rapid diagnosis of

primary pulmonary choriocarcinoma in a man. Chest. 2002; 121(3) 996-998.

Yatabe Y, Mitsudomi T, Takashashi T. TTF-1 expression in pulmonary

adenocarcinomas. Am J SurgPathol. 2002; 26(6):767-773.

Sridha KS, Saldana MJ, Thurer RJ, Beattie EJ. Primary choriocarcinoma of the lung:report

of a case treated with intensive multimodality therapy and review of the literature. J Surg

Oncol. 1989; 41:93-97.


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