A Unique Case of Thrombotic Thrombocytopenic Purpura (TTP) Associated With Plasmodium vivax Malaria

Dawit Kebede Huluka, Lalise Gemechu Nemie, Fissehatsion Tadesse Woldegebriel, Addisu Melkie Ejigu, Charles Bruce Sherman


Thrombotic thrombocytopenic purpura (TTP) is a rare disease characterized by capillary thrombosis and a pentad of findings: microangiopathic anemia, thrombocytopenia, acute renal failure, fever, and fluctuating neurologic abnormalities. We report the unusual case of a young woman with both TTP and Plasmodium vivax malaria. A causal relationship between these two diseases remains unclear. Early recognition of TTP in patients suspected to have malaria requires a high index of suspicion, which is crucial for initiating lifesaving treatment. To our knowledge, this is the first case report in Africa of TTP associated with Plasmodium vivax malaria.

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