A report of four Ethiopian patients with Plummer – Vinson syndrome

Abdulsemed Mohammed Nur, Yohannes Birhanu Gebremeskel


Plummer–Vinson syndrome (PVS) is a rare condition characterized by a triad of dysphagia, iron deficiency anemia, and upper esophageal web. The post-cricoid web is associated with increased risk of development of squamous cell carcinoma of the esophagus. In this presentation, we report four Ethiopian patients with PVS. The patients presented with dysphagia, iron deficiency anemia and typical endoscopic features of the syndrome; the patients were treated with endoscopic dilation and oral iron replacement.

Key words: Dysphagia, anemia, upper esophageal web, Plummer–Vinson syndrome

Full Text:



Atmatzidis K, Papaziogas B, Pavlidis T, Mirelis Ch, Papaziogas T. Plummer-Vinson syndrome. Dis Esophagus 2003; 16: 154-7.

Geerlings SE, Statius van Eps LW. Pathogenesis and consequences of Plummer-Vinson syndrome. Clin Investig 1992; 70: 629-30.

Wynder EL, Hultberg S, Jacobsson F, Bross IJ: Environmental factors in cancer of the upper alimentary tract. A Swedish study with special reference to Plummer-Vinson (Paterson-Kelly) syndrome. Cancer 1957, 10:470-482.

Chen TS, Chen PS: Rise and fall of the Plummer-Vinson syndrome. J Gastroenterol Hepatol 1994, 9:654-658.

Nosher JL, Campbel WL, Seaman WB: The clinical significance of cervical esophageal and hypopharyngeal webs. Radiology 1975,117:45-47.

Hoffmann RM, Jaffe PE: Plummer-Vinson syndrome. A case report and literature review. Arch Intern Med 1995,155:2008-111.

NJ, Jani P, Bailey CM: Plummer-Vinson syndrome – a rare presentation in a child. J Laryngol Otol 1999, 113:475-476.

Anthony R, Sood S, Strachan DR, Fenwick JD: A case of Plummer-Vinson syndrome in childhood. J Pediatr Surg 1999,34:1570-1572.

Lopez Rodriguez MJ, Robledo Andres P, Amarilla Jimenez A, Roncero Maillo M, Lopez Lafuente A,Arroyo Carrera I: Sideropenic dysphagia in an adolescent. J Pediatr Gastroenterol Nutr 2002,34:87-90.

Gottfried Novacek Review Plummer-Vinson syndrome Orphanet Journal of Rare Diseases 2006, 1:36.

Dantas RO, Vilanova MG. Esophageal motility impairment in Plummer-Vinson syndrome. Correction by iron treatment. Dig Dis Sci 1993; 38(5): 968-71.

Remacha A, Souto JC, Ortuno F, et al. [Pernicious anemias with subtle or atypical presentations]. Sangre (Barc)1992; 37(2): 109-13.

Dickey W, McConnell B. Ceilac disease presenting as the Paterson-Brown Kelly (Plummer-Vinson ) syndrome. Am J Gastroenterol 1999; 94(2): 527-9.

Sanai FM, Mohammed AE, Al Karawi MA. Dysphagia caused by Plummer-Vinson syndrome. Endoscopy 2001; 33: 470.

Beyler AR, Yurdaydin C, Bahar K, et al. Dilation therapy of upper esophageal webs in two cases of Plummer-Vinson syndrome. Endoscopy 1996; 28(2): 266-7.

Uygur-Bayramicli O, Tuncer K, Dolapcioglu C. Plummer-Vinson syndrome presenting with an esophageal stricture. J Clin Gastroenterol 1999; 29(3): 291-2.

Ribeiro U Jr, Posner MC, Safetle-Ribeiro AV, et al. Risk factors for squamous cell carcinoma of the esophagus. Br J Surg 1996; 83: 1174-85.

Rashid Z, Komar A, Komar M. Plummer-Vinson syndrome and post-cricoid carcinoma: late complications of unrecognized celiac disease. Am J Gastroenterol 1999; 94: 1991.


  • There are currently no refbacks.

Comments on this article

View all comments

Kirkos Sub-City, Woreda 05
Roosevelt street, Infront of Africa Union main gate
Tel: +251 115 533742 Fax: +251 115 151005
P.O.Box 2179 Email: info@emaemj.org
Copyright © Ethiopian Medical Association 2018 All rights Reserved

Powered by OJS & Designed and Hosted by MAKE Enterprise