SERUM LEVEL OF β-hCG IN NORMOTENSIVE AND PREECLAMPTIC PREGNANT WOMEN IN TIKUR ANBESSA SPECIALIZED HOSPITAL

Abebaw Nigussie Ayele, Tewabech Zewde, Yirgu G/Hiwot

Abstract


Introduction: Preeclampsia remains a major cause of prenatal morbidity and mortality worldwide. It is considered to be a likely trophoblastic disorder and since β-hCG is secreted by trophoblastic cells, its serum level may be essential in diagnosing preeclampsia. Hence the aim of this study was to determine serum levels of β-hCG in normotensive and preeclamptic pregnant women.

Methods: A case control study was conducted in TikurAnbessa Specialized Hospital from June, 2013 to March, 2014. Cases were preeclamptic pregnant women and controls were normotensive pregnant women. Serum levels of β-hCG were determined by an electrochemiluminescence immunoassay, , and compared among the patient groups. Binary logistic regression and bivariate correlation analysis were done to determine associations between  β-hCGother obstetric factors.

Results: A total of 76 pregnant women (38 cases and 38 controls) were included in this study. Mean serum levels of β-hCG in the case group was 34439.2+/- 28223.67mIU/ml and significantly higher that of the control group,20582 +/-17588.31. Serum levels of β-hCG in the case group was positively correlated with mean arterial blood pressure and negatively correlated with maternal age, gestational age and parity. Witha cutoff point of 12,953mIU/ml, the sensitivity and specificity of maternal serum level of β-hCG as a diagnostic test for preeclampsia was 76.3% and 52.6% respectively.

Conclusions: In this study, maternal serum level of β-hCGand family history of preeclampsia were significantly associated  preeclampsia.

Key words: Preeclampsia, normotensive, human chorionic gonadotropin.

 


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