MALIGNANT CARCINOID SYNDROME IN A YOUNG PATIENT WITH LIKELY MESENTERIC PRIMARY- A RARE TUMOR WITH UNCOMMON PRESENTATION

Tesfaye Kebede legesse, Guda Merdassa, Tufa Gemechu, Endale Kassa

Abstract


Gastrointestinal Carcinoid is a rare neoplasm initially manifesting with non-specific abdominal symptoms making diagnosis usually delayed for many years. As a result, one third of patients are diagnosed with metastasis. We report a young female who presented with three years duration of typical clinical features of flushing, watery diarrhea and carcinoid heart disease. Diagnosis was confirmed by findings of mesenteric mass, multiple liver masses, elevate durinary 5-HIAA level and typical immunohistopathologic findings on special staining of sample obtained from the liver mass. This is a typical example of delayed diagnosis of the disease making treatment extremely difficult.

Key words: malignant carcinoid, mesenteric.

 


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References


Jennifer Ha1, Tan WA. Gastrointestinal Carcinoid Tumours: A Review. Journal of Gastrointestinal & Digestive System. 1970.

Mocellin S, Nitti D. Gastrointestinal carcinoid: epidemiological and survival evidence from a large population-based study (n = 25 531). Annals of oncology : official journal of the European Society for Medical Oncology. 2013 Dec;24(12):3040-4. PubMed PMID: 24050954. Epub 2013/09/21. eng.

Hauso O, Gustafsson BI, Kidd M, et al. Neuroendocrine tumor epidemiology: contrasting Norway and North America. Cancer. 2008 Nov 15;113(10):2655-64.

Maroun J, Kocha W, Kvols L, Bjarnason G, Chen E, Germond C, et al. Guidelines for the diagnosis and management of carcinoid tumours. Part 1: The gastrointestinal tract. A statement from a Canadian National Carcinoid Expert Group. Current Oncology. 2006 Apr;13(2):67-76. PubMed PMID: 17576444.

Ramage JK, Ahmed A, Ardill J, Bax N, Breen DJ, Caplin ME, et al. Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs). Gut. 2012;61(1):6-32.

Srirajaskanthan R, Shanmugabavan D, Ramage JK. Carcinoid syndrome. BMJ. 2010;341.

Liu EH, Solorzano CC, Katznelson L, Vinik AI, Wong R, Randolph G. AACE/ACE disease state clinical review: diagnosis and management of midgut carcinoids. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2015 May;21(5):534-45.


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